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ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers.
Vermeer PD, Bell M, Lee K, Vermeer DW, Wieking BG, Bilal E, Bhanot G, Drapkin RI, Ganesan S, Klingelhutz AJ, Hendriks WJ, Lee JH. Vermeer PD, et al. PLoS One. 2012;7(1):e30447. doi: 10.1371/journal.pone.0030447. Epub 2012 Jan 18. PLoS One. 2012. PMID: 22279592 Free PMC article.
Here we show that PTPN13 regulates a new signaling complex in breast cancer consisting of ErbB2, Src, and EphrinB1. ...Decreased PTPN13 function further enhances signaling. The association of oncogene kinases (ErbB2, Src), a signaling transmembrane ligand (EphrinB1) …
Here we show that PTPN13 regulates a new signaling complex in breast cancer consisting of ErbB2, Src, and EphrinB1. ...Decreased P …
Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB/EFNB1 complex.
Vermeer PD, Colbert PL, Wieking BG, Vermeer DW, Lee JH. Vermeer PD, et al. Cancer Res. 2013 Sep 15;73(18):5787-97. doi: 10.1158/0008-5472.CAN-13-0760. Epub 2013 Jun 28. Cancer Res. 2013. PMID: 23811940 Free PMC article.
Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylation and downstream signaling persists in the presence of cetuximab. ...Together, our findings suggest that EFNB1 is part of the EGFR signali …
Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylation and …
EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity.
Colbert PL, Vermeer DW, Wieking BG, Lee JH, Vermeer PD. Colbert PL, et al. Oncotarget. 2015 Jan 20;6(2):953-68. doi: 10.18632/oncotarget.2823. Oncotarget. 2015. PMID: 25436983 Free PMC article.
We have previously demonstrated that the HPV16 E6 oncoprotein binds PTPN13 and leads to its degradation. Thus, we speculated that HPV infection may affect cellular proliferation by altering the localization of a PTPN13 phosphatase substrate, EphrinB1, during mitosis …
We have previously demonstrated that the HPV16 E6 oncoprotein binds PTPN13 and leads to its degradation. Thus, we speculated that HPV …
Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1.
Xing W, Kim J, Wergedal J, Chen ST, Mohan S. Xing W, et al. Mol Cell Biol. 2010 Feb;30(3):711-21. doi: 10.1128/MCB.00610-09. Epub 2009 Dec 7. Mol Cell Biol. 2010. PMID: 19995908 Free PMC article.
Mutations of ephrin B1 in humans result in craniofrontonasal syndrome. Because little is known of the role and mechanism of action of ephrin B1 in bone, we examined the function of osteoblast-produced ephrin B1 in vivo and identified the …
Mutations of ephrin B1 in humans result in craniofrontonasal syndrome. Because little is known of the role and mechanism of ac …
The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif.
Lin D, Gish GD, Songyang Z, Pawson T. Lin D, et al. J Biol Chem. 1999 Feb 5;274(6):3726-33. doi: 10.1074/jbc.274.6.3726. J Biol Chem. 1999. PMID: 9920925 Free article.
In vitro studies demonstrated that the fifth PDZ domain of FAP-1 and full-length syntenin bound ephrin B1 via the carboxyl-terminal motif. Lastly, syntenin and ephrin B1 could be co-immunoprecipitated from transfected COS-1 cells, suggesting that PDZ d …
In vitro studies demonstrated that the fifth PDZ domain of FAP-1 and full-length syntenin bound ephrin B1 via the carboxyl-ter …